... corrugation, or fissure, it might almost be called, had indented his brow, rising from the commencement of his nose towards the centre of the forehead. And he knew it was his brooding thought, his fierce, hard determination, his intense concentrativeness for so many months, that had been digging that furrow; and it must prove indeed a potent specific of the life-water that would smooth that away, and restore him all the youth and elasticity that he had buried ... — Septimius Felton - or, The Elixir of Life • Nathaniel Hawthorne